Podosomes at a glance.

Invadosomes at a glance.

This article is part of a Minifocus on invadopodia and podosomes. For further reading, please see related articles: ‘Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia’ by Renaud Poincloux et al. (J. Cell Sci. 122, 3015-3024), ‘Mechanisms for transcellular diapedesis: probing and pathfinding by ‘invadosome-like protrusions’’ by Christopher V. Carman (J. Cell Sci. 122...

Chemicals and Infertility at a Glance

The University of Social Welfare and Rehabilitation Sciences at a Glance

The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes.

Podosomes are actin-rich adhesion structures that depend on Arp2/3-complex-based actin nucleation. We now report the identification of the formins FHOD1 and INF2 as novel components and additional actin-based regulators of podosomes in primary human macrophages. FHOD1 surrounds the podosome core and is also present at podosome-connecting cables, whereas INF2 localizes at the podosome cap struct...

Cancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis

Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. ...